He has never lost a PGA Tour event when he had at least a share of the 54-hole lead.
Reed made three bogeys in a seven-hole stretch in the middle of his round and salvaged an even-par 71, giving him a two-shot lead over Seung-yul Noh, Freddie Jacobson and Marc Leishman going into the final round.
He was at 6-under 207.
Reed will try to become the only player with four PGA Tour victories in the last year, and history is on his side. He won the Wyndham Championship when tied for the lead going into Sunday, and he converted a seven-shot lead at the Humana Challenge and a two-shot lead at Doral into victories.
Reed matched the highest score to par for a 54-hole leader in a tour event at Congressional. The other time was in 1983 at the old Kemper Open.
Noh finished off his 5-under 66 — the best score of the third round — about the time the leaders went off. He was at 4-under 209, which looked better by the hour.
Jacobson made four birdies in his opening eight holes to reach 8 under, only to take double bogey on the 11th hole and a sloppy bogey on the par-5 16th hole. He wound up with a 71. Leishman was still only one shot behind until he failed to get up-and-down for par on the 17th and fell to a 73.
Senior Players Championship: Bernhard Langer moved closer to his first Senior Players victory, shooting a 4-under 66 in the third round to stay in front of defending champion Kenny Perry.
Langer was at 15-under 195 through 54 holes in the third Champions Tour major of the season.
Perry, trying to join Arnold Palmer as the only player to win the Senior Players in consecutive years, briefly took the lead midway through the round before settling for a 65 that left him three strokes behind.
Russ Cochran, Joe Durant and Bill Glasson were four back. Cochran had a 63, the low round of the day at Fox Chapel. Durant shot 67, and Glasson had a 68.
NW Arkansas Championship: Michelle Wie shot her second straight 5-under 66 to take a two-shot lead in the suspended second round.
Coming off a victory Sunday in the U.S. Women’s Open at Pinehurst, Wie had six birdies and a bogey in her morning round at Pinnacle Country Club.
So Yeon Ryu, paired with Wie, was second after her second straight 67.
All 72 players in the afternoon session were unable to finish because of thunderstorms.
BMW International Open: Spain’s Pablo Larrazabal shot a 5-under 67 to take a three-stroke lead into the final round.
Larrazabal, the 2011 winner at Munich Eichenried, had a 17-under 199 total at Gut Larchenhof.
Sweden’s Henrik Stenson (66) and Robert Karlsson (68) were tied for second with Spain’s Carlos Del Moral (66) and Rafa Cabrera-Bello (70), Australia’s Richard Green (62), Italy’s Francesco Molinari (65), Denmark’s Thomas Bjorn (66) and Argentina’s Emiliano Grillo (70).