It was the fourth time the brothers have homered in the same game as teammates, tying a major league record.
B.J. Upton’s homer was a solo shot off Scott Feldman (3-5) in the third inning that put Atlanta up 2-1. Younger brother Justin connected off Feldman the next inning to push the lead to 3-1.
It was a nice bounce-back game for the brothers, who were coming off a four-game series against Washington, in which they went a combined 2-for-27.
Aaron Harang (6-6) allowed two runs and six hits in six innings. Craig Kimbrel pitched a scoreless ninth for his 22nd save.
Houston rookie George Springer hit his team-leading 14th home run and Jose Altuve added two hits to give him a major league-best 105.
Former Astro Chris Johnson had two hits and drove in the first run for the Braves.
Springer put Houston up 1-0 with his two-out homer to center field in the first inning.
The Braves tied it in the second when Jason Heyward tripled and scored on a double by Johnson.
Jason Castro singled with one out in the Houston fourth, Chris Carter walked and Jonathan Villar hit an RBI single.
The Astros got a runner to third base with two outs in both the seventh and eighth innings, but stranded them. Springer grounded out the first time and Robbie Grossman struck out in the eighth.
Feldman allowed four hits and three runs with five strikeouts in six innings for his third straight loss.
Matt Dominguez, rookie Jon Singleton and Grossman continue to struggle at the plate for Houston. Dominguez was 0-for-3 with a walk to extend his slump to-0-for 19, Singleton went 0-for-4 and is 0-for-16 and Grossman is 0-for-24 after going 0-for-4 with three strikeouts.
Justin Upton also had a nifty defensive play for the second out of the eighth inning. He made a long dash from left field to grab a ball hit by Castro in foul territory down the line before spinning around throwing the ball in.
NOTES: Other brothers who have homered in the same game four times are Jeremy and Jason Giambi and Vladimir and Wilton Guerrero. This is the second season the Uptons have played on the same team. ... Braves manager Fredi Gonzalez said that RHP Gavin Floyd, who broke a bone in his throwing elbow Thursday, will have elbow surgery today. Gonzalez said that he isn’t sure of the timetable for his return. ... SS Carlos Correa, the No. 1 overall pick by Houston in 2012, is expected to be out for an extended time after injuring his right ankle Saturday night playing for Single-A Lancaster. Astros general manager Jeff Luhnow said Correa was in Houston on Tuesday to see a doctor and that he’d have more details on his injury today.