Wesley Saunders led the Crimson (27-4) with 12 points as Harvard pulled off an upset for the second straight year. Last year, Harvard upset New Mexico as a 14 seed.
The Crimson became the first Ivy League school with NCAA tournament wins in consecutive years since Princeton in 1983-84.
Michigan St. 93, Delaware 78: Adreian Payne scored a career-high 41 points to get Michigan State off to a solid start.
Payne, a 6-foot-10 senior, scored 12 straight points in the first half to help the fourth-seeded Spartans (27-8) to an 18-point lead.
He set an NCAA tournament record by making all 17 of his free throws and broke the program’s tournament scoring record, set previously by Greg Kelser in 1979.
Connecticut 89, Saint Joseph’s 81 (OT): Shabazz Napier shook off a miss at the second-half buzzer to score nine of his 24 points in overtime and lead seventh-seeded Connecticut to a win over Saint Joseph’s.
DeAndre Daniels scored 18 while freshman center Amida Brimah forced overtime by completing a three-point play in the final minute for UConn (27-8). The Huskies won their first tournament game under coach Kevin Ollie, who took over two years ago after Jim Calhoun stepped down due to health issues.
With the game tied at 70 entering overtime, Daniels opened the scoring by completed a three-point play with 3:47 left during a 5-minute period the Huskies never trailed.
Dayton 60, Ohio St. 59: Vee Sanford scored on a layup with 3.8 seconds left to lift 11th-seeded Dayton.
Sanford finished with 10 points, while Dyshawn Pierre led the Flyers (24-10) with 12 points in a matchup of Ohio schools separated by about 75 miles.
The sixth-seeded Buckeyes (25-10) had one last chance to pull out the victory, but Aaron Craft’s driving 10-footer hit off the backboard and rolled off the rim as the buzzer sounded.
Syracuse 77, Western Michigan 53: Syracuse’s backcourt of Trevor Cooney and Tyler Ennis combined for 34 points and the Orange defense clamped down.
Western Michigan (23-10),
the Mid-American Conference champion, had won 14 of 16 games and was in the NCAA tournament for the first time in a decade.
The third-seeded Orange (28-5) forced 11 turnovers in the opening half and scored 13 points off them in running out to a double-digit lead before the midpoint of the period.
Pittsburgh 77, Colorado 48: Talib Zanna scored 16 of his 18 points in the opening half, helping ninth-seeded Pittsburgh build a 28-point lead.
The Panthers (26-9) shot 51 percent and played stifling defense.
Colorado (23-12) was eager to make amends for an early exit from the tournament a year ago, but had no answers for the 6-foot-9 Zanna. The Pitt center made six of seven shots in the first half, and the Panthers didn’t have any difficulty finishing off the overwhelmed Buffaloes.
Florida 67, Albany 55: Dorian Finney-Smith scored 16 points, most of them on dunks, and top-seeded Florida used a second-half surge to beat 16th-seeded Albany.
The Gators (33-2) showed some vulnerability, though, while extending their school-record winning streak to 27 games.
Coach Billy Donovan’s team sleepwalked through the first half, swapping the lead back and forth with the pesky Great Danes, but Florida’s bench provided a much-needed spark.
Wisconsin 75, American 35: Ben Brust scored 17 points and second-seeded Wisconsin devastated American with a 22-5 run to close the first half.
The second-seeded Badgers (27-7) recovered from a brief first-half rut and seven-point deficit to extinguish the dreams of the 15th-seeded Eagles (20-13).
Oregon 87, BYU 68: Elgin Cook scored a career-high 23 points for seventh-seeded Oregon.
Joseph Young had 19 points for the Ducks (24-9),
who had to stage a big comeback to beat the Cougars 100-96 in overtime in December. There was no comeback needed this time, with Oregon turning away every charge by BYU in the second half.
North Dakota St. 80, Oklahoma 75 (OT): Lawrence Alexander hit a 3-pointer with 11 seconds left to force overtime and freshman Carlin Dupree scored four points in the final 75 seconds as No. 12 seed North Dakota State knocked off Oklahoma.
The Bison (26-6) picked up their first NCAA tournament win by rallying in the final minute and then outlasting the No. 5 seed Sooners in overtime. Alexander finished with a career-high 28 points, but it’ll be his falling-down, fist-pumping celebration after the tying 3-pointer that will be replayed in Fargo for years.
Saint Louis 83, N.C. State 80 (OT): Rob Loe scored 22 points and grabbed 15 rebounds, helping St. Louis wipe out a late 14-point deficit and pull away in overtime to beat North Carolina State.
Jordair Jett overcame a slow start to score 18, doing most of his damage while the fifth-seeded Billikens (27-6) were making their comeback in the last five minutes of regulation.