The FBI says the U.S. currency was stolen sometime between June 21 and June 24 as it was being moved from Switzerland to New York.
The currency shipment was brought to John F. Kennedy International Airport on board a Swiss International Air Lines flight.
The money was discovered missing after a count at the Federal Reserve showed a discrepancy.
The case also is being investigated by police at the Port Authority, which runs the airport.
Copyright 2013 The Associated Press.